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Journal of Experimental Biology 163,85-95 (1992)
Published by Company of Biologists 1992

L-SERINE UPTAKE BY TROUT (SALMO TRUTTA) RED BLOOD CELLS: THE EFFECT OF ISOPROTERENOL

M. A. GALLARDO ¹, J. PLANAS ², and J. SÁNCHEZ ²

¹ Departament de Bioquímica i Fisiologia, Unitat de Fisiologia, Facultat de Biologia Diagonal 645, 08028-Barcelona, Spain
² Departament de Bioquimica i Fisiologia, Unitat de Fisiologia, Facultat de Biologia Diagonal 645, 08028-Barcelona, Spain

To whom reprint requests should be addressed

We studied the uptake of L-serine by trout red blood cells and the effect of a µ-adrenergic agonist (isoproterenol) on this process. The results obtained indicate that L-serine is taken up by these cells by means of a concentrative process. The uptake seems to be mediated both by a sodium-dependent process and by a sodium-independent process. The sodium-dependent uptake is mediated by a transport system that probably belongs to the ASC system family. Isoproterenol exerts an inhibitory effect on L-serine uptake. This effect is dose-dependent. It is proposed that the inhibitory effect of isoproterenol is mediated by a rise in the intracellular sodium concentration and/or changes in cell volume.

Key words: L-serine, trout, red blood cells, catecholamines, isoproterenol, Salmo trutta

Accepted on October 14, 1991