QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by CLEMENTS, D. I. Articles by HOWES, N. H. Search for Related Content PubMed Articles by CLEMENTS, D. I. Articles by HOWES, N. H.

Journal of Experimental Biology 15,541-554 (1938)
Published by Company of Biologists 1938

Anterior Pituitary And Growth In The Axolotl (Amblystoma Tigrinum (Green) Neotenic Form) : I. The Effects Of Injection Of Growth-Promoting Extracts Of The Anterior Pituitary

D. I. CLEMENTS ¹ and N. H. HOWES ¹

¹ Department of Zoology and Comparative Anatomy, University College, London

1. The effects of injection of (a) Schockaert's extract of anterior pituitary, (b) Van Dyke & Wallen-Lawrence's phyone and (c) prolactin, upon the growth of larval neotenic Amblystoma tigrinum, have been investigated. The normal growthrate was established before injections were begun and controls were injected with muscle extract.

2. The dosage adopted in all cases was equivalent to 1 mg. of fresh tissue per gram of axolotl per day. This was probably supramaximal.

3. Schockaert's extract and phyone caused a marked increase in the rate of growth, prolactin a slight increase.

4. Of the ten animals injected with Schockaert's extract, all except one showed some of the signs usually associated with metamorphosis in A. tigrinum. The other experimental animals did not.

5. In no case were there any abnormal changes in the bodily proportions or in the shape of the skeleton.

6. The growth of half the animals after injections had been stopped was also investigated. In the case of most of the animals injected with Schockaert's extract or with phyone, there was a loss of weight, followed by recovery and growth in the case of the latter only. The prolactin-injected animals showed no such reaction.