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Journal of Experimental Biology 145,185-197 (1989)
Published by Company of Biologists 1989

The Movement of Cadmium Through Freshwater Trout Branchial Epithelium and its Interference with Calcium Transport

P. M. VERBOST ¹, J. VAN ROOIJ ¹, G. FLIK ¹, R. A. C. LOCK ¹, and S. E. WENDELAAR BONGA ¹

¹ University of Nijmegen, Department of Animal Physiology, Faculty of Science, Toernooiveld 25, 6525 ED Nijmegen, The Netherlands

Exposure of freshwater trout (Salmo gairdneri) to waterborne Cd²⁺ results in accumulation of the metal in the branchial epithelial cells and its appearance in the blood. Cd²⁺ apparently enters the cells via Ca²⁺ channels in the apical membrane. Transfer of Cd²⁺ through the basolateral membrane is probably by diffusion. Inhibition by Cd²⁺ of transepithelial Ca²⁺ influx is time- and Cd²⁺-concentration-dependent. The inhibition of transepithelial Ca²⁺ influx is accompanied by blockage of apical Ca²⁺ channels. In line with the assumption that cytosolic Cd²⁺ inhibits Ca²⁺ uptake by inhibiting the basolateral Ca²⁺ pump, we hypothesize that the blockage of Ca²⁺ channels is an indirect effect of Cd²⁺ and results from a rise in cytosolic Ca²⁺ level caused by inhibition of the basolateral membrane Ca²⁺ pump.

Key words: freshwater teleost fish, gills, calcium transport, cadmium

Accepted on May 25, 1989

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