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Journal of Experimental Biology 142,257-266 (1989)
Published by Company of Biologists 1989

Time Course of Failure and Resumption of Excitatory and Inhibitory Transmission in the Denervated Muscle Fibres of the Cockroach

HIROSHI WASHIO 1

1 Laboratory of Neurophysiology, Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo 194, Japan

1. Functional changes in neuromuscular transmission following denervation of the coxal depressor muscle of the cockroach Periplaneta americana have been studied by intracellular recording.

2. Miniature postsynaptic potentials, both excitatory (MEPSPs) and inhibitory (MIPSPs), disappeared by about 24h following nerve section or crush when animals were maintained at 26°C. Generally this was accompanied by the disappearance of excitatory and inhibitory junctional potentials.

3. When animals were kept at 15°C, the onset of failure was delayed markedly, and excitatory transmission ceased a few days before inhibitory transmission, as found previously.

4. Excitatory transmission resumed before inhibitory transmission: in animals maintained at 26°C after nerve crush, MEPSPs reappeared at 11 days and MIPSPs at 28 days. The resumption of transmission was accompanied by the reappearance of junctional potentials.

5. It appears likely that the differences between excitatory and inhibitory transmission, in the timing of failure and of resumption of potentials, are related to the sizes of the axons innervating the coxal muscle of the insect leg.

Key words: denervation, regeneration, neuromuscular transmission, cockroach muscle

Accepted on November 9, 1988






© The Company of Biologists Ltd 1989