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Journal of Experimental Biology 140,199-208 (1988)
Published by Company of Biologists 1988

Hypocalcaemic Activity of Trout Hypocalcin and Bovine Parathyroid Hormone in Stanniectomized Eels

FLORIS P.J. G. LAFEBER 1, R.G.J. M. HANSSEN 2, and S. E. WENDELAAR BONGA 2

1 Department of Animal Physiology, Faculty of Science, University of Nijmegen Toernooiveld 25, 6525 ED Nijmegen, The Netherlands; Laboratory for Cell Biology and Histology, University of Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands
2 Department of Animal Physiology, Faculty of Science, University of Nijmegen Toernooiveld 25, 6525 ED Nijmegen, The Netherlands

Hypocalcin isolated from trout corpuscles of Stannius (CS) and bovine parathyroid hormone (bPTH) induce hypocalcaemia when injected intra-arterially in hypercalcaemic, stanniectomized (STX) eels. On a molar basis, both hormones have almost the same potency. Upon injection of hypocalcin we observed a decrease in blood ionic calcium level which fully accounts for the decrease in total calcium. Injections of bPTH also resulted in a decrease of total and ionic calcium concentrations in the blood. The decrease in ionic calcium level upon injection of bPTH, however, did not fully account for the decrease in total calcium concentration of the blood. Nevertheless, hypocalcin and bPTH showed striking similarity in bioactivity in stanniectomized eels. Some similarity in three-dimensional structure of both hormones may underlie this phenomenon.

Key words: hypocalcin, PTH, corpuscles of Stannius, eel, calcium, trout

Accepted on March 1, 1988






© The Company of Biologists Ltd 1988