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Journal of Experimental Biology, Vol 138, Issue 1 259-269, Copyright © 1988 by Company of Biologists

JOURNAL ARTICLES

The action of vasoactive intestinal peptide antagonists on peptidergic modulation of the squid Schwann cell

PD Evans and J Villegas
Department of Zoology, University of Cambridge.

1. The effects of two specific antagonists of vasoactive intestinal peptide (VIP) receptors were investigated on the VIP-induced hyperpolarization of the membrane potential of the Schwann cell of the giant nerve fibre of the tropical squid. 2. Both (pCl-D-Phe6,Leu17)VIP and (N-Ac-Tyr1,D-Phe2)-GRF(1-29)amide competitively and reversibly blocked the effects of VIP in this preparation with the former compound being more potent than the latter. 3. The blocking actions of both antagonists were specific for the responses of this preparation to VIP. They did not block the actions of carbachol, DL-octopamine or substance P. 4. Both antagonists also reduced the effectiveness of an endogenous VIP-like component in the normal hyperpolarizing action of giant axon activity on the membrane potential of the Schwann cell, with the same potency ratio as for their actions on the effects induced by the exogenous application of VIP.


This article has been cited by other articles:


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 J. Exp. Biol.Home page
P. Evans, V Reale, R. Merzon, and J Villegas
A comparison of the release of a vasoactive-intestinal-peptide-like peptide and acetylcholine in the giant axon-Schwann cell preparation of the tropical squid Sepioteuthis sepioidea
J. Exp. Biol., January 2, 1999; 202(4): 417 - 428.
[Abstract] [PDF]


© The Company of Biologists Ltd 1988