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Journal of Experimental Biology, Vol 132, Issue 1 59-78, Copyright © 1987 by Company of Biologists

JOURNAL ARTICLES

Mechanisms of glial regeneration in an insect central nervous system

PJ Smith, EA Howes and JE Treherne
AFRC Unit of Insect Neurophysiology and Pharmacology, Department of Zoology, Cambridge, UK.

As in other repairing systems, glial regeneration in insect central nervous connectives, following selective chemical lesioning, involves both exogenous and endogenous elements. Our current evidence, including that obtained with monoclonal antibodies, indicates that the reactive, granule-containing cells are derived from a sub-population of circulating haemocytes which, within 24 h, invade, and are restricted to, the lesion zone. The granule-containing cells are involved in the initial repair of the perineurial region. They also contribute to the first stage in the restoration of the blood-brain barrier and are responsible for recruiting reactive endogenous glia, apparently from the vicinity of the anterior abdominal ganglion. The granule-containing cells transform into or are replaced by functional glia between 3 and 5 days after selective glial disruption, coincident with the appearance in the lesion zone of dividing reactive cells.


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© The Company of Biologists Ltd 1987