spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kuffler, D. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kuffler, D. P.

Journal of Experimental Biology, Vol 132, Issue 1 151-160, Copyright © 1987 by Company of Biologists

JOURNAL ARTICLES

Long-distance regulation of regenerating frog axons

DP Kuffler
Department of Pharmacology, University of Basel, Switzerland.

Following a nerve crush, damaged frog motor axons regenerate to reinnervate their denervated muscle fibre targets. The axons do this by growing down their old nerve tubes to their former synaptic sites. It is the naked basal lamina of the nerve tube that appears to direct the regenerating axons by providing a substratum over which the axons will preferentially grow. Another possible mechanism for directing the regenerating axons to the end-plates is the release of molecular signals by the cells of the nerve tube or by the denervated muscle fibres. This paper provides evidence that chemical signals do direct the regeneration process. Such signals, released several millimetres from a growing nerve tip, cause it to change direction and bend towards the source. Both the cells of the nerve tube and the denervated muscle fibres release diffusible substances and thereby establish a gradient that affects the regenerating axons.


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S. L. Tam, V. Archibald, B. Jassar, N. Tyreman, and T. Gordon
Increased Neuromuscular Activity Reduces Sprouting in Partially Denervated Muscles
J. Neurosci., January 15, 2001; 21(2): 654 - 667.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1987