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Journal of Experimental Biology 13,1-6 (1936)
Published by Company of Biologists 1936

The Diabetogenic Hormone of the Pituitary Gland

DAVID SLOME ¹

¹ Department of Social Biology, the University of London, and the Buckston Browne Research Farm, Royal College of Surgeons of England

1. The normal fasting level of the blood glucose of toads kept on a black background was significantly higher than that of toads on a white background.

2. After hypophysectomy the blood sugar was within normla limits.

3. An increased tolerance for glucose was demonstrated after extirpation of the pituitary gland.

4. The diabetic manifestations which follow pancreatectomy in the normal toad did not develop or developed only to a mild degree if the toad had previously been hypophysectomised.