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Journal of Experimental Biology 129,239-250 (1987)
Published by Company of Biologists 1987

Phenyliminoimidazolidine Derivatives Activate Both Octopamine₁ and Octopamine₂ Receptor Subtypes in Locust Skeletal Muscle

PETER D. EVANS ¹

¹ AFRC Unit of Insect Neurophysiology and Pharmacology, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ

1. The actions of the phenyliminoimidazolidine derivatives, NC7 and NC5 on octopamine receptors in the extensor-tibiae neuromuscular preparation of the locust are described.

2. The derivatives activate both OCTOPAMINE₁ and OCTOPAMINE₂ receptors in this preparation. They are not selective agonists of OCTOPAMINE₂ receptors that activate adenylate cyclase.

3. The relative potencies of NC5 and NC7 on OCTOPAMINE₁ and OCTOPAMINE₂ receptors differ, suggesting that they may be useful in the development of selective agonists that can distinguish between the different pharmacological subclasses of octopamine receptor.

4. The octopamine-mediated increases in cyclic AMP levels in this preparation can be separated into high- and low-affinity components. NC5 and NC7 appear to activate the high-affinity component of this response selectively.

Key words: phenuliminoimidazolidines, octopamine receptors, insect muscle

Accepted on February 5, 1987