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Journal of Experimental Biology 123,325-344 (1986)
Published by Company of Biologists 1986

Glucose Transport by the In Vitro Perfused Midgut of the Blue Crab, Callinectes Sapidus

KA HOU CHU ¹

¹ Department of Biology, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA; Department of Biology, The Chinese University of Hong Kong, Shatin, N.T. Hong Kong

1. The midgut of Callinectes sapidus is capable of net transmural glucose absorption.

2. The mucosal glucose influx by the midgut has a sodium-dependent, saturable component and a sodium-independent, non-saturable counterpart.

3. The unidirectional mucosal to serosal flux and the mucosal influx of glucose are depressed by metabolic inhibitors, the presence of mucosal phlorizin or serosal ouabain.

4. The low rate of net transmural glucose flux and the kinetic characteristics of mucosal influx suggest that the midgut does not play an important role in total nutrient absorption.

5. Thin layer chromatographic analysis shows that most of the glucose appears as phosphorylated forms upon entering the midgut, suggesting that the efflux of free glucose across the serosal border requires an active mechanism.

Key words: glucose transport, gut transport, midgut, Callinectes sapidus

Submitted on February 3, 1986