spacer gif spacer gif spacer gif spacer gif Online submission spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hennessey, T. M.
Right arrow Articles by Kung, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hennessey, T. M.
Right arrow Articles by Kung, C.

Journal of Experimental Biology, Vol 110, Issue 1 169-181, Copyright © 1984 by Company of Biologists

JOURNAL ARTICLES

An anticalmodulin drug, W-7, inhibits the voltage-dependent calcium current in Paramecium caudatum

TM Hennessey and C Kung

The anticalmodulin drug, W-7 [N-(6 aminohexyl)-5-chloro-1-naphthalenesulphonamide] specifically inhibits the voltage-dependent Ca-current of Paramecium as well as the behavioural consequence of Ca2+ influx, backward swimming. The dechlorinated analogue, W-5, is four to five times less effective. Analysis of membrane currents under voltage clamp shows that W-7 not only reversibly inhibits the voltage-dependent Ca-current but also shifts the voltage sensitivity of this Ca-current towards less negative voltages in a concentration-dependent manner. We suggest that Paramecium can be used as a system to screen behaviourally for other Ca-channel blockers as well as to study the mechanism of action of these drugs.


This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
P. Ramoino, L. Gallus, F. Beltrame, A. Diaspro, M. Fato, P. Rubini, S. Stigliani, G. Bonanno, and C. Usai
Endocytosis of GABAB receptors modulates membrane excitability in the single-celled organism Paramecium
J. Cell Sci., May 15, 2006; 119(10): 2056 - 2064.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
R. Hinrichsen, A Burgess-Cassler, B. Soltvedt, T Hennessey, and C Kung
Restoration by calmodulin of a Ca2+-dependent K+ current missing in a mutant of Paramecium
Science, April 25, 1986; 232(4749): 503 - 506.
[Abstract] [PDF]


© The Company of Biologists Ltd 1984