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Journal of Experimental Biology, Vol 105, Issue 1 363-371, Copyright © 1983 by Company of Biologists

JOURNAL ARTICLES

Haemodynamic effects of adrenaline on the isolated, perfused head of the dogfish 'pup' (Squalus acanthias)

DH Evans and JB Claiborne

The isolated, perfused head of the dogfish 'pup' (Squalus acanthias) maintained pressure:flow relationships near to those described for the in vivo adult for at least 3 h when perfused at a constant rate. The addition of 3% polyvinylpyrrolidone reversibly increased branchial resistance, and the postbranchial outflow (arterial + venous) equalled the inflow. 10(-5) M adrenaline reversibly reduced gill resistance (in some cases after a transient increase in resistance) and stimulated perfusate outflow from the dorsal aorta, at the expense of flow from the cephalic and branchial venous system. Phentolamine did not alter the effect of adrenaline on pressure and flow pattern; addition of propranolol inhibited both adrenaline effects and resulted in a slight increase in afferent pressure, indicating that alpha-adrenergic receptors are present, but that the dominant haemodynamic effects are mediated via beta-adrenergic receptors. The isolated, perfused 'pup' head may provide a vehicle for investigation of transport phenomena in the elasmobranch branchial epithelium.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. H. Evans and M. P. Gunderson
A prostaglandin, not NO, mediates endothelium-dependent dilation in ventral aorta of shark (Squalus acanthias)
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1998; 274(4): R1050 - R1057.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1983