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Journal of Experimental Biology 10,59-66 (1933)
Published by Company of Biologists 1933

The Permeability and Haemolytic Action of the Fatty Acids and Some of their Halogen Derivatives

M. BODANSKY ¹

¹ The John Sealy Memorial Research Laboratory and the University of Texas School of Medicine, Galveston.

The permeability of the red blood corpuscle for fatty acids has been studied by the haemolysis method. It has been found that in spite of certain limitations the method may be applied to the study of various factors, such as the effects of pH, concentration, temperature and buffer content of the corpuscles. If account is taken of the possibilities for error and the experiments are adequately controlled, the results have a quantitative significance.

For a given concentration the halogen derivatives are more effective than the fatty acids in producing haemolysis, but no definite relationship of concentration to haemolytic effect has been determined for these compounds. They are apparently taken up by the red cells more readily than the fatty acids, as might be expected from their greater solubility in lipoids. It has not been possible, however, quantitatively to evaluate these differences in permeability.