Fig. 1. Multiple alignment of the amino terminal end of CD14. Boxes 1–4 represent hydrophobic motifs that are part of the lipopolysaccharide (LPS) binding site. Boxes 5 and 6 represent motifs involved in Toll-like receptor 4 (TLR4) interactions. Asterisks indicate the shared potential N-linked glycosylation sites; marsupial-specific sites are underlined. Plus signs indicate the residues involved in the LPS binding pocket. Sequences used in the alignment are detailed in Table 2.