Fig. 6. Circularized RGD-peptides modulate oxidative burst in the injured nerve. (A–C, left panels) Phase contrast photomicrographs showing the injured RIP nerve cultured in ABS only, 1 µmol l^–1 cGRGDSPA and 100 µmol l^–1 cGRGDSPA, respectively. Arrows indicate crush zones. (A–C, right panels) Corresponding CM-H₂DCF fluorescence signal of the nerves shown in the left panels. (D) Average CM-H₂DCF fluorescence intensity of preparations cultured for 1 h in ABS only, ABS + 1 µmol l^–1 cGRGDSPA or ABS + 100 µmol l^–1 cGRGDSPA. (E) Average CM-H₂DCF fluorescence intensity of preparations cultured for 48 h in ABS only, ABS + 1 µmol l^–1 cGRGDSPA or ABS + 100 µmol l^–1 cGRGDSPA. Note the attenuated CM-H₂DCF fluorescence signal in the preparations cultured in the presence of 1 µmol l^–1 cGRGDSPA. Image acquisition conditions were exactly the same for all preparations. Scale bar in A–C, 100 µm.