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Fig. 1. (A) Pufferfish FXYD (pFXYD) nucleotide sequence and deduced amino acid
sequence. The transmembrane domain is shaded gray; the predicted signal
peptide is underlined; the circle indicates the site for phosphorylation; the
boxes indicate the highly similar FXYD motif and two glycine residues (G39 and
G50). (B) Phylogenetic tree of pFXYD with known human FXYD members and related
EST sequences from various teleost fish. Accession numbers are: shark PLMS,
CAD88978; human FXYD1, NP_005022; human FXYD2.a, NP_001671;
human FXYD2.b, NP_067614; human FXYD3, NP_005962; human
FXYD4, NP_775183; human FXYD5, NP_054883; human
FXYD6, NP_071286; human FXYD7, NP_071289; zebrafish
EST-FXYD6, AW153757; zebrafish EST-FXYD8, AI958251;
zebrafish EST-FXYD9, AW455046; medaka EST-FXYD.a, AU169681;
medaka EST-FXYD.b, AU169966; Fugu EST-FXYDa,
CA332188; Xenopus FXYD1, NP_001011320.
