Fig. 1. Neuronal responses to naltrindole during anoxia. For each panel the top trace (membrane potential, E_m) and the middle trace (change in cytosolic [Ca²⁺], [Ca²⁺]_c) correspond to the same treatment regime, as indicated by the solid black bars. The whole-cell NMDAR currents (bottom trace) were recorded at the time points indicated by a, b or c on the E_m trace within the same panel. All experiments were conducted on individual cortical sheets exposed to (A) normoxia, (B) anoxia, (C) normoxia plus naltrindole, (D) anoxia plus naltrindole, (E) anoxia plus naltrindole in the presence of the NMDAR antagonist 2-amino-5-phosphonopentanoic acid (APV), or (F) anoxia plus naltrindole in the presence of the G_i agonist mastoparan-7 (MP7).