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Figure 1


Fig. 1. Pairwise alignments of Amblyomma americanum (Aam) Oatp and Ixodes scapularis (Isc) Oatp1 amino acid sequences. As outlined in the Results section, IscOatp1 is one of the three full sequences that we have annotated from the I. scapularis genome. In our preliminary alignment, IscOatp2 and IscOatp3 showed less than 30% identity to AamOatp and they were excluded from this alignment. Similar and identical amino acid residues are highlighted in black. Transmembrane domains (TM1 to TM12) are double underlined by broken lines. The 11 conserved cysteine residues located between TM9 and TM10 are indicated by an asterisk. + indicates the putative N-glycosylation site. The Oatp/OATP protein family signature amino acid motif D-X-RW-(I,V)-GAWW-X-G-(F,L replaced by Y)-L (replaced by I) is boxed.