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Figure 7


Fig. 7. Loss or cardiac knockdown of mlp84B results in heart rhythm abnormalities. (A) M-mode representations of heart contractions recorded in wild-type, mlp84B–/–, UAS-mlp84B-RNAi/+ and tinC{Delta}4>mlp84B RNAi flies. Asystole and tachyarrhythmia are shown by arrowheads and arrows, respectively. (B) The frequency of fibrillation is higher in 5 week old mlp84B RNAi-expressing flies than in age-matched UAS-mlp84B-RNAi/+ or wild-type control flies. (C) Asystole is observed in 1 week old mlp84B–/– flies but not wild-type flies. The occurrence of asystole is reduced when the mlp84B transgene is reintroduced in the mlp84B–/– background. (D) Five week old Drosophila expressing mlp84B RNAi in the heart show a high rate of asystole compared with wild-type or UAS-mlp84B-RNAi/+ flies.