Fig. 2. Clustal alignments of invertebrate putative salivary adenosine deaminase (ADA) of P. duboscqi (PduM73 and PduM74), Lutzomyia longipalpis, Aedes aegypti, Aedes albopictus and Culex pipiens and mammalian ADA (mouse, rat and human). Arrowheads indicate conserved amino acids located in the active site of the mammalian enzyme. Black shading indicates amino acid sequence identity, and gray regions indicate conserved amino acid substitutions.