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Figure 1


Fig. 1. Hypothesized mechanism of interaction of E2, ER-{alpha} and strain in osteoblasts. Left, E2 levels are lower and osteoblasts express fewer ER-{alpha} receptors, decreasing strain sensitivity. Right, higher E2 upregulates osteoblast expression of ER-{alpha}, increasing strain sensitivity and causing greater osteogenic response to identical mechanical loading.