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Figure 1


Fig. 1. Maximum likelihood analyses of the vertebrate preproendothelin amino acid sequences. Following the WAG model of amino acid substitutions (Whelan and Goldman, 2001) and a gamma=1.023, there are three distinct groups of preproendothelins, preproendothelin-1 (abbreviated as only EDN1 to save space), preproendothelin-2 (EDN2) and preproendothelin-3 (EDN3). Numbers at nodes represent the percent bootstrap (BS=500 replications). GenBank accession or Ensembl numbers: Chicken EDN1, XP_418943; chicken EDN2, XP_417707; chicken EDN3, XP_001231488; frog EDN1, AAS13535.1; frog EDN3, AAS13536.1; human EDN1, NP_001946; human EDN2, NP_001947; human EDN3, NP_000105; killifish EDN1A, EU009474; killifish EDN1B, EU009475; medaka EDN1, ENSORLP00000011633; medaka EDN2, ENSORLP00000010557; medaka EDN3, ENSORLP00000011814; mouse EDN1, NP_034234; mouse EDN2, P22389; mouse EDN3, NP_031929; rat EDN1, NP_036680; rat EDN2, NP_036681; rat EDN3, NP_001071118; salmon EDN1, BAF30875.1; Takifugu EDN2, NEWSINFRUP00000182956; Takifugu EDN3, NEWSINFRUP00000181774; Tetraodon EDN3, GSTENT00028275001; Tetraodon EDN2, GSTENT00026224001; Zebrafish EDN1, NP_571594; Zebrafish EDN2, NP_001038650. Scale bar represents the number of replacements per site.