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Figure 1


Fig. 1. Alignment of AgCA9 with AgCA6, AgCA10 and AgCA11, formally cloned by the Linser laboratory. Also included are Homo sapiens CAII (HCAII) and Drosophila melanogaster CAI (DrosCAI). Alignment was performed in ClustalX and visualized using Genedoc. Similarity groups were enabled using the default scoring matrix, Blosum 62 matrix. Regions with high similarity are highlighted in blue (100%). Regions of lesser similarity are highlighted in red (>80%) and yellow (>60%). The three histidines essential for {alpha}-CA activity are indicated with a star (HCAII his-94, his-96, his-119). The black bars indicate antigenic sites against which antibodies (5340 and 5563) were generated.