Fig. 3. Structure-based sequence alignment of Lospins with native antithrombin (1AZX, chain I). Structure-based pairwise alignments between Lospins deduced and 1AZX amino acid sequences retrieved from the protein data bank (PDB), were done using Expresso (Armougom et al., 2006). Due to limitations on space, representative alignments only are shown here. Secondary structures were assigned based on 1AZXi (PDB). `H', -helix; `E', beta-strand. Helices are labeled from `hA' to `hI', ß-strands that constitute ß-sheet A are labeled as `sA', `sB' for ß-sheet B and `sC' for ß-sheet C. Highly conserved residues that correspond to the 51 core residues shown in Fig. 1 are indicated by an asterisk (^*). Please note that s3c and s1B, s2C and s6A as well as s4B and s5B are merged and continuous, to denote boundaries; s1B, s6A and s5B are underlined.