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Figure 1


Fig. 1. Conservation of core serpin superfamily residues (Irving et al., 2000) in deduced Lospin proteins. The serpin superfamily archetype, {alpha}1-antitrypsin ({alpha}1-ATT, accession no. AAB59495) was aligned with deduced Lospin (L) proteins using Vector NTI (Invitrogen) and conserved residues were manually aligned. L1–L17=Lospins 1–17. The minus sign (–) denotes conservation of the specific amino acid residues. Replaced residues are indicated. Numbering is based on {alpha}1-ATT. E%C denotes the expected % conservation at that position (Irving et al., 2000).