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Figure 1


Fig. 1. Nucleotide and deduced amino acid sequences of Homarus americanus prepro-sulfakinin. Within the coding region of the cDNA (bold font), both the start (ATG) and stop (TAA) codons are underlined, as are the two polyadenylation signal sequences (AATAA) present in the 3'-UTR. The predicted amino acid sequence of the prepro-hormone signal peptide is shown in italics. Predicted cleavage sites within the preprohormone are shown in black. The amino acid sequence, including the C-terminal glycine residue which serves as a target for {alpha}-amidation, of Homarus americanus sulfakinin I (Hoa-SK I) is shown in blue, while that of Homarus americanus sulfakinin II (Hoa-SK II), including its C-terminal glycine, is shown in red. The amino acid sequences of three putatative Homarus americanus sulfakinin-precursor related peptides [Hoa-SPRPs I, II and III (named based on their relative positions within the prepro-hormone)] are shown in green (including the C-terminal glycine residue of Hoa-SPRP II). Within the amino acid sequence of the prepro-hormone, the position of the stop codon is denoted with an asterisk.