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Figure 3


Fig. 3. Stability of R70pRomiLuc in Atlantic cod blood after intravenous administration (A) and in vitro in whole blood (B). Supercoiled (SC) and open circular (OC) topoform were reduced to linear (L) topoform and degradation products, both in vitro and in vivo. M, molecular marker 1 kb plus (Invitrogen); N, negative control (blood without R70pRomiLuc); S, standard (R70pRomiLuc). The negative control demonstrates that there is no detectable endogenous pDNA in the blood.