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Figure 5


Fig. 5. Tension recordings showing the effect of nicotine (A-C), rANP (B) and SNP (C) on the crocodile dorsal aorta in the presence of ODQ (B) and L-NNA (C). The aortae were pre-treated with ODQ (10-5 mol l-1) or L-NNA (10-4 mol l-1) for approximately 10 min before being constricted with ET-1 (10-8 mol l-1). Once maximal constriction was achieved, nicotine (3x10-4 mol l-1) was added, followed by either rANP (10-8 mol l-1), which was added to the vessels pre-treated with ODQ, or SNP (10-4 mol l-1), which was added to the vessels pre-treated with L-NNA. The nicotine-mediated vasodilation was abolished in the presence of ODQ or L-NNA, but rANP and SNP both induced a potent vasodilation in the presence of ODQ and L-NNA, respectively (N=5).