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Figure 4


Fig. 4. Tension recordings showing the effect of ACh (A-D), SNP (A-D) and rANP (B) on the crocodile right aorta in the presence of ODQ (B), L-NNA (C) and atropine (D). The aortae were pre-treated with ODQ (10-5 mol l-1), L-NNA (10-4 mol l-1) or atropine (10-6 mol l-1) for approximately 10 min before being constricted with ET-1 (10-8 mol l-1). Once maximal constriction was achieved, ACh (10-5 mol l-1) was added, followed by SNP (10-4 mol l-1); rANP was added to vessels pre-treated with ODQ only. The ACh-mediated vasodilation was abolished in the presence of ODQ, L-NNA and atropine, whereas the SNP-mediated vasodilation was only abolished by ODQ. Rat ANP induced a potent vasodilation in the presence of ODQ (N=5).