Fig. 2. Changes in pH_i in isolated toad myocytes subjected to hypercapnic acidosis in the absence or presence of Na⁺/H⁺ exchanger (NHE) inhibition. (A) In the the absence of cariporide, the initial fall in pH_i was followed by restitution towards the 5% CO₂ values, in spite of the persistent extracellular acidosis. No pH_i recovery was observed in the presence of cariporide (5 µmol l^–1). (B) Overall results of five experiments of this type. *P<0.05 with respect to values with cariporide.