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Figure 8


Fig. 8. Change in levels of intracellular cGMP in tubules stimulated with 5-HT alone or in combination with Mas-CAPA-1 (500 nmol l–1) or Fraction 25 (F25; 10 CNS equivalents) vs saline alone. 5-HT lowers cGMP levels, and these levels can be restored to those with saline alone or above by Mas-CAPA-1 or Fraction 25 (*significantly different from 5-HT alone at P<0.05). In addition, levels of intracellular cGMP in tubules stimulated with Fraction 25 were also significantly higher ({dagger}) than tubules stimulated with Mas-CAPA-1 or saline alone (P<0.05).