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Figure 8


Fig. 8. The actions of pevkinin-2 on the pyloric rhythm are dose dependent. (Left) PevK-2 application had dose-dependent actions on the pyloric cycle frequency. As shown in Fig. 5, PevK-2 (10-6 mol l-1) increased the pyloric cycle frequency relative to saline controls. However, the pyloric cycle frequency was unchanged during application of lower peptide concentrations. (Right) PevK-2 superfusion increased the number of LP neuron spikes/burst in a dose-dependent manner. The threshold concentration for PevK-2 enhancement of LP neuron activity (10-7 mol l-1), relative to levels during saline superfusion, was lower than for pyloric cycle frequency (10-6 mol l-1). The mean number of LP neuron spikes/burst was also larger when PevK-2 was applied at 10-6 mol l-1 than at 10-7 mol l-1 (N=6 or 7 for each concentration; *P<0.005, {dagger}P<0.05).