Fig. 10. The LP neuron regulates the speed of the pevkinin-modulated pyloric rhythm.
(Left) Scatter plot comparing the pyloric cycle frequency when the LP neuron
was active and silent, during both saline superfusion (pre-PevK-2, open
squares; post-PevK-2, open triangles) and PevK-2 (10-6 mol
l-1) application (filled circles). The LP neuron was silenced
via hyperpolarizing current injection (see
Fig. 9). During saline
superfusion, suppressing LP neuron activity generally did not alter the mean
pyloric cycle frequency. Note that these data points lie along the diagonal,
unity line. By contrast, during PevK-2 superfusion, suppressing LP neuron
activity consistently increased the pyloric cycle frequency relative to times
during the same preparation when the LP neuron was active. (Right) Across
preparations, the mean pyloric cycle frequency during saline superfusion was
unchanged by suppressing LP neuron activity. However, during PevK-2
application, suppressing LP neuron activity did increase the pyloric cycle
frequency. Both examined conditions during PevK-2 application resulted in
faster pyloric rhythms than either condition examined during saline
superfusion (N=9; *P<0.05,
**P<0.001).