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Figure 9


Fig. 9. Dopamine and TPep-NLS decrease total whole cell current amplitude. (A) Whole cell current recordings from CPE cells in a seawater bath. (B) Same cell after exposure to 100 µmol l-1 dopamine. (C) Normalized I-V 900 ms into voltage step reveals that dopamine (DA) reduces current amplitude at all voltages that the currents are activated (before dopamine, circles; after dopamine, squares; N=7). (C,inset) Dopamine caused a significant decrease in maximum current amplitude at 73 mV (N=7, P<0.001). (D) Whole cell current recordings from CPE cells in a seawater bath. (E) Same cell after exposure to 10 µmol l-1 TPep-NLS. (F) Normalized I-V 900 ms into voltage step reveals that TPep-NLS reduces current amplitude at all voltages the currents are activated (before TPep-NLS, squares; after TPep-NLS, circles; N=7). (F,inset) TPep-NLS caused a significant decrease in maximum current amplitude at 73 mV (N=10, P<0.001).