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Figure 8


Fig. 8. Dopamine increases CBF. (A) Raw voltage recordings from transducer measuring CBF. Each oscillation represents a cilium passing in front of the transducer. Dopamine increases the rate of oscillation and therefore CBF. (B) Dose-response for concentrations of dopamine applied to CPE cell explants show a maximal excitatory effect on CBF around 100 µmol l-1. High concentrations (10 mmol l-1, N=6) and low concentrations (1 µmol l-1, N=5) did not change CBF. The middle concentrations all show significant increases in CBF compared to seawater controls (10 µmol l-1 N=5, P=0.0001; 100 µmol l-1 N=5, P=0.0003; 1 mmol l-1 N=6, P=0.0001). (C) Dopamine causes a significant increase in the CBF (N=5, P=0.0002) of isolated CPE cells.