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Figure 10


Fig. 10. Dopamine and TPep-NLS selectively reduce the Cl- current of CPE cells. (A) Representative current traces and their double exponential fits from one cell before and after exposure to 100 µmol l-1 dopamine during a 63 mV depolarization. (B) Amplitudes for each of the two exponentials, corresponding to the previously established current types found in CPE cells, before and after exposure to dopamine (N=7). Dopamine selectively lowers the amplitude of the fast activating Cl- current by 55%. (C) Representative current traces and their double exponential fits from one cell before and after exposure to 10 µmol l-1 TPep-NLS during a 63 mV depolarization. (D) Amplitudes for each of the two exponentials, corresponding to the previously established current types found in CPE cells, before and after exposure to TPep-NLS (N=8). TPep-NLS selectively lowers the amplitude of the fast activating Cl- current by 49%.