Fig. 4. Analysis of heterogeneity. (A) Unstimulated and (B) stimulated example close-ups of different network configurations resulted from activity driven plasticity. A variety of methods can be used to analyze synaptic distribution, including analysis of heterogeneity, variance and clustering, as well as more sophisticated modeling of the spatial distribution, which incorporate techniques such as Fourier transforms. (C,D) Examples of a Delauney triangulation of regions of clustered synapses, induced following overnight stimulation of the network, illustrating how pattern analysis can be performed to address network development using this technology.