Fig. 3. Long-term potentiation (LTP) evoked by multiple bursts of stimulation is deficient in some strains of mice. LTP elicited by four 1 s bursts of 100 Hz, interburst interval 20 s, (4x 100 Hz@20s) is reduced in 129/SvEms (A, N=7 mice, 7 slices), DBA (B, N=7 mice, 7 slices) and CBA (C, N=10 mice, 12 slices) as compared to B6 (N=5 mice, 5 slices) hippocampi. Baseline fEPSPs measured during stimulation of a neighbouring pathway that did not experience high-frequency stimulation (no HFS) were unaffected in each strain tested. The B6 curve in A is repeated in B and C for comparison with other strains. Sample sweeps to the right are synaptic responses measured at 90 min post-induction. Taken from (Nguyen et al., 2000b). (Copyright 2000, The American Physiological Society, used with permission.)