Fig. 3. Immediate cooling after training session 2 (TS2) blocks memory boosting. (A) Cooling snails immediately after ITM-training prevents the establishment of an ITM memory trace sufficient for a second bout of ITM-training to produce LTM. (B) When the cooling was administered after the consolidation process had occurred (i.e. 2 h after TS2) LTM was apparent 24 h later (MT). *Significant difference in number of openings from control TS1 and TS3.