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Fig. 4. Effects of combining inhibitors of the IP3 receptor with an inhibitor of NAD(P)H oxidase (DPI) or a superoxide scavenger (TEMPOL) in Ca2+-free shark Ringers. In each case, the combination of antagonists blocked the [Ca2+]i response to endothelin-1 (ET-1) by 83±1%. *P<0.01.