Fig. 3. Effect of NAD(P)H oxidase inhibitor (DPI) and superoxide dismutase mimetic
(TEMPOL) on endothelin-1 (ET-1) stimulation of [Ca2+]i
in shark vascular smooth muscle (VSM). (A) Typical tracing of the
[Ca2+]i response to ET-1 in the presence and absence of
DPI. (B) Typical tracing of the ET-1 in the presence and absence of TEMPOL.
(C) Summary data showing the inhibitory effects of DPI (N=19) and
TEMPOL (N=19) on the ET-1 induced elevation of
[Ca2+]i. *P<0.01 for ET-1 plus
DPI or TEMPOL vs ET-1 alone.