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Fig. 7. Evolutionary relationships of human mucus carbonic anydrase. Distances between protein sequences were not corrected for underestimated multiple mutations. Tree was built by the neighbor-joining method using a 68 amino acid alignment of the three human mucus CA peptides with selected CA isozyme sequences. The numbers on the branches represent the bootstrap replicates; only values above 75% are shown (for details see Hewett-Emmett and Tashian, 1996). GenBank protein sequence accessions: human CA I, II, III, XIII are given in the Fig. 6 legend; human CA IV (#P22748); CA VA (#NP_001730), CA VB (#NP_009151), CA VII (#P43166); Macaca nemestrina CA I (#P35217); mouse CA I (#NP_033929), CA II (#NP_033931), CA III (#NP_031632), CA IV (#P031633), CA VA (#NP_031634), CA VB (#NP_851832), CA VII (#NP_444300), CA XIII (#AAK16672); sheep CA I (#P48282); turtle CA I (cf. Table 1 in Hewett-Emmett and Tashian, 1996). *Bootstrap value <50%. {dagger}50%< bootstrap value <75%. Bold: bootstrap values >85% and support clustering of different CA genes.