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Fig. 8. Effects of WIN 55,212-2 and 2-AG ether on activation and inactivation of the Na+ currents. (A) Voltage dependence of activation before and after superfusion with 10 µmol l–1 WIN 55,212-2. V1/2=–48.6 mV, k=–5.1 mV for control (open squares), V1/2=–37.0 mV, k=–5.0 mV for WIN 55,212-2 (filled circles). (B) Voltage dependence of inactivation before and after superfusion with 10 µmol l–1 WIN 55,212-2 (filled circles). V1/2=–76.9 mV, k=8.1 mV for control (open squares), V1/2=–94.4 mV, k=9.0 mV for WIN 55,212-2. (C) V1/2 of activation before (white bars) and after superfusion with each drug (hatched bars). (D) V1/2 of inactivation before (white bars) and after superfusion with each drug (hatched bars). Values are means ± S.E.M. Numerals within parentheses are number of the cells sampled.