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Fig. 10. Effect of 10 µmol l–1 PDBu on activation and inactivation of the Na+ currents. (A) Voltage dependence of activation. V1/2=–47.7 mV, k=–5.3 mV for control (open squares), V1/2=–44.3 mV, k=–6.0 mV for PDBu (filled circles). (B) Voltage dependence of inactivation. V1/2=–81.8 mV, k=8.1 for control (open squares), V1/2=–93.7 mV, k=9.0 mV for PDBu (filled circles). Values are mean ± S.E.M. obtained from 5–8 cells.