JEB -- Inoue et al. 208 (24): 4577 Figure IG8

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Fig. 8. Time course of recovery of K⁺ current from inactivation. (A) Upper panel: protocol of the double pulses stimulation. Two-step depolarisations from the holding potential of –70 mV to +30 mV with the interval of ${Delta}$ t were applied. Lower panel: K⁺ currents in response to double-pulse stimulation ( ${Delta}$ t=10 s). Amplitude of the 2nd K⁺ current (right) was $~$ 50% of the 1st current (left). (B) Relationship between the recovery of K⁺ current amplitude and ${Delta}$ t. The curve was fitted with an equation of experimental decay, I( ${Delta}$ t)/I₀=1–exp(– ${Delta}$ t/ ${tau}$ ), where I( ${Delta}$ t)/I₀ is the relative amplitude of K⁺ current after an interval time of ${Delta}$ t (s), and ${tau}$ is the time constant in s for K⁺ current recovery. The value of ${tau}$ is 13.2 s. The bath solution was N-Ca-free-ASW containing 4 µmol l^–1 TTX, and the pipette solution was K-asp. Cell membrane capacitance (C_m)=143.2 pF.