Fig. 3. Alternative RNA splicing of some of the msslo gene products. (A) Schematic diagram of the Slowpoke protein. The hydrophobic core (S0-S6), S4 voltage sensor (+) and hydrophobic tail (S7-S10) containing the RCK domain and calcium bowl are evolutionarily conserved among Slo proteins. Approximate locations of the five alternate splice regions within the tail region that are conserved among insects (A, C, E, G, I) are indicated by black boxes. (B) Alternative forms for msslo regions E, G, I. While some of the exon sequences are conserved among insects, those that are unique to Manduca sexta are denoted with an asterisk (^*).