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Fig. 3. Effects of bolus intra-arterial injections of ET-1 on the maximum change in (A) total cardiac output (tot), (B) heart rate (fH), (C) total stroke volume (VStot) and (D) pul/sys as a function of the amount of peptide injected. Data points show means ± S.E.M. for seven individual experiments. The asterisks denote a significant difference (P<0.05) from the pre-injection value.