Fig. 2. Effects of bolus intra-arterial injections of ET-1 on the maximum change in mean arterial systemic and pulmonary pressures, (A) P_sys and (D) P_pul, respectively; systemic and pulmonary blood flows, (B) _sys and (E) _pul; systemic and pulmonary vascular conductances, (C) G_sys and (F) G_pul as a function of the amount of peptide injected. Data points show means ± S.E.M. for eight (systemic variables) and six (pulmonary variables) individual experiments. The asterisks denote a significant difference (P<0.05) from the pre-injection value.