Fig. 7. Expression of genes in total nic^b107 embryos as fold increase versus gene expression in total wild-type embryos during the first four days of development. Expression of (A) col12 (collagen type 1 2) and (B) col21 (collagen type 2 1) is indicated by black bars. Expression of sarcomere components (C) mylz2 (myosin light chain 2); (D) myhz2 (fast muscle specific myosin heavy chain 2); (E) myhz5 (slow muscle specific myosin heavy chain 5); (F) mylz3 (fast muscle specific myosin light chain 3); (G) titin; (H) tropC fast (fast muscle specific troponin C) and (I) tropC slow (slow muscle specific troponin C) is indicated by grey bars. Expression of growth factors (J) IGF-1 Ea2 (insulin-like growth factor splice form Ea2); (K) IGF-Ra (insulin-like growth factor receptor a) and (L) IGF-Rb (insulin-like growth factor receptor b); (M) gdf8 (growth and differentiation factor 8/myostatin) and (N) myogenin is indicated by vertically shaded bars. Expression of (O) oxygen carrier myoglobin, (P) muscle-specific glycolysis enzyme pfk-m (phosphofructokinase in muscle); and mitochondria specific oxidative phosphorylation genes (Q) SDHa (succinate dehydrogenase a) and (R) NADHd (diaphorase) are indicated by open bars. All scales are linear, except in M, which is logarithmic. Values are means of five embryos + S.D. A dotted line indicates where the fold increase is one and no difference exists between expression in nic^b107 and wild-type embryos. Asterisks indicate significant difference between nic^b107 and wild-type expression (P<0.05).